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What Is Levothyroxine?

Levothyroxine is a synthetic thyroid hormone used to treat hypothyroidism, a condition in which the thyroid gland doesn't produce enough thyroid hormone.
The drug is available under the brand names Levothroid, Levoxyl, Levo-T, Synthroid, Tirosint, and Unithroid.
Thyroid hormones affect the metabolism of protein, fats, and carbohydrates. They also affect a person's growth and development.
If untreated, hypothyroidism can lead to poor growth, slow speech, loss of energy, weight gain, hair loss, dry skin, and increased sensitivity to cold temperatures.
Levothyroxine can help reverse these symptoms. The drug can also help treat the congenital form of hypothyroidism, as well as an enlarged thyroid gland (goiter) and thyroid cancer.
Levothyroxine has been available in the United States since the 1950s, but the Food and Drug Administration (FDA) didn't approve it until 2000. 

 LevothyroxineImportant information

You may not be able to take levothyroxine if you have certain medical conditions. Tell your doctor if you have an untreated or uncontrolled adrenal gland disorder, a thyroid disorder called thyrotoxicosis, or if you have any recent or current symptoms of a heart attack.


Levothyroxine Warnings
Thyroid hormone is not a treatment for obesity, and people with normal thyroid function should not take levothyroxine.
If you have a healthy thyroid and take levothyroxine, you could develop life-threatening side effects. This is particularly true if you take the drug with amphetamines.
Although levothyroxine treats an underactive thyroid, it's not a cure for the condition. You should also understand that it may take several weeks before you see an improvement in your symptoms.
Women on long-term levothyroxine therapy may be at greater risk for osteoporosis. Over time, the drug can lead to a decrease in bone mineral density.
A study published in 2014 in the Journal of Preventive Medicine & Public Health investigated the link between the risk for broken bones and levothyroxine use among older women with underactive thyroids.
The researchers concluded that doctors should be particularly concerned about the overuse of levothyroxine in older women with osteoporosis.
Before taking levothyroxine, tell your doctor if you've ever had:
  • Diabetes
  • Heart disease, such as atherosclerosis (“hardening of the arteries”)
  • High blood pressure
  • Chest pain (angina)
  • Irregular heartbeat
  • Heart attack
  • Kidney disease
  • Hepatitis
  • Underactive adrenal or pituitary gland
  • Blood-clotting disorders

Let your doctor know if you have any type of surgery planned.
People with heart disease, or older people at greater risk for heart disease, may need a lower dose of levothyroxine.

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Levothyroxine side effects
Get emergency medical help if you have any signs of an allergic reaction to levothyroxine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
  • fast or irregular heart rate;
  • fever, hot flashes, sweating;
  • sleep problems (insomnia);
  • changes in your menstrual periods; or
  • vomiting, diarrhea, appetite changes, weight changes.
Common levothyroxine side effects may include mild hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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What other drugs will affect levothyroxine?

Many other medicines can be affected by your thyroid hormone levels. Other medicine may also increase or decrease the effects of levothyroxine.
Many drugs can interact with levothyroxine and not all possible interactions are listed in this medication guide.
Tell your doctor about all medications you use, start using, or stop using during your treatment with this medicine. This includes prescription, over-the-counter, vitamin, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
  
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